The Histone Methyltransferase Mixed Lineage Leukemia (MLL) 3 May Play a Potential Role in Clinical Dilated Cardiomyopathy

摘要: Histone modifications play a critical role in the pathological processes of dilated cardiomyopathy (DCM). While and expression pattern histone methyltransferases (HMTs), especially mixed lineage leukemia (MLL) families on DCM are unclear. To this end, twelve normal fifteen heart samples were included present study. A murine cardiac remodelling model was induced by transverse aortic constriction (TAC). Real-time PCR performed to detect levels MLL mouse human left ventricles. The mRNA level MLL3 significantly increased hearts treated TAC surgery. Compared with hearts, higher protein detected its closely associated ventricular end systolic diameter (LVEDD) ejection fraction (LVEF). However, other (MLL, MLL2, MLL4, MLL5, SETD1A, SETD1B) had no obvious change between control or remodeled hearts. Furthermore, di-methylated H3 lysine 4 (H3K4me2) but not H3K4me3 Smad3, GATA4, EGR1, which might regulate MLL3, remarkably elevated Our hitherto unrecognized findings indicate that has potential via regulating H3K4me2 EGR1.