Tumor Suppressor Role of KiSS-1 in Bladder Cancer: Loss of KiSS-1 Expression Is Associated with Bladder Cancer Progression and Clinical Outcome
作者： Marta Sanchez-Carbayo , Paola Capodieci , Carlos Cordon-Cardo
DOI: 10.1016/S0002-9440(10)63854-0
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摘要: The expression profiles of nine bladder cancer cell lines were compared against a pool containing equal total RNA quantities each them. Lower KiSS-1 was revealed in cells derived from the most advanced tumors. When comparing 15 primary tumors versus four lines, lower transcript levels observed invasive carcinomas as to superficial ratios provided prognostic information. pattern transcripts analyzed using situ hybridization cells, paired normal urothelium and tumor samples (n = 25), tissue microarrays 173). We complete loss all under study their respective urothelium. found be significantly associated with histopathological stage. Patients showed direct correlation overall survival subset whose follow-up available 69). did not observe any significant differential along cycle by sorting analysis. A potential suppressor role for KiSS-1. Moreover, it predictive value identifying patients poor outcome.
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