The KISS1 metastasis suppressor: mechanistic insights and clinical utility
作者： Kevin T Nash , Danny R Welch
DOI: 10.2741/1824
关键词:
摘要: Melanoma is a highly metastatic cancer that accounts for the majority of skin deaths. Unfortunately, very few improvements have been made during last 20 years in management melanoma metastases, which major cause Therefore, identification molecular targets can be exploited clinic to treat disease desperately needed. The KISS1 metastasis suppressor gene has emerged as promising target disease. This review compiles data regarding and biochemical properties its cognate receptor, focusing on believed most pertinent use clinical setting. In addition, supports having dual role prognostic indicator therapeutic will highlighted.
bioscience.org参考文章(54)
Meenhard Herlyn, Molecular events in melanoma development and progression Frontiers in Bioscience. ,vol. 3, pp. d1005- 1010 ,(1998) , 10.2741/A341
Marta Sanchez-Carbayo, Paola Capodieci, Carlos Cordon-Cardo, Tumor Suppressor Role of KiSS-1 in Bladder Cancer: Loss of KiSS-1 Expression Is Associated with Bladder Cancer Progression and Clinical Outcome American Journal of Pathology. ,vol. 162, pp. 609- 617 ,(2003) , 10.1016/S0002-9440(10)63854-0
Hiroyuki Nakamura, Hirohisa Ueno, Hirohisa Ueno, Masaki Inoue, Kazushi Imai, Hiroshi Sato, Motoharu Seiki, Yasunori Okada, Masakuni Noguchi, Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Human Invasive Breast Carcinomas Cancer Research. ,vol. 57, pp. 2055- 2060 ,(1997)
Tetsuya Ohtaki, Yasushi Shintani, Susumu Honda, Hirokazu Matsumoto, Akira Hori, Kimiko Kanehashi, Yasuko Terao, Satoshi Kumano, Yoshihiro Takatsu, Yasushi Masuda, Yoshihiro Ishibashi, Takuya Watanabe, Mari Asada, Takao Yamada, Masato Suenaga, Chieko Kitada, Satoshi Usuki, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura, Masahiko Fujino, Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. ,vol. 411, pp. 613- 617 ,(2001) , 10.1038/35079135
Steven F. Goldberg, John F. Harms, Kim Quon, Danny R. Welch, Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate. Clinical & Experimental Metastasis. ,vol. 17, pp. 601- 607 ,(1999) , 10.1023/A:1006718800891
Meenhard Herlyn, Gloria Balaban, Jeannette Bennicelli, DuPont Guerry IV, Ruth Halaban, Dorothee Herlyn, David E Elder, Gerd G Maul, Zenon Steplewski, Peter C Nowell, Wallace H Clark, Hilary Koprowski, Primary Melanoma Cells of the Vertical Growth Phase: Similarities to Metastatic Cells Journal of the National Cancer Institute. ,vol. 74, pp. 283- 289 ,(1985) , 10.1093/JNCI/74.2.283
Sandrine Funes, Joseph A Hedrick, Galya Vassileva, Lisa Markowitz, Susan Abbondanzo, Andrei Golovko, Shijun Yang, Frederick J Monsma, Eric L Gustafson, The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system Biochemical and Biophysical Research Communications. ,vol. 312, pp. 1357- 1363 ,(2003) , 10.1016/J.BBRC.2003.11.066
Yasuko Horikoshi, Hirokazu Matsumoto, Yoshihiro Takatsu, Tetsuya Ohtaki, Chieko Kitada, Satoshi Usuki, Masahiko Fujino, Dramatic Elevation of Plasma Metastin Concentrations in Human Pregnancy: Metastin as a Novel Placenta-Derived Hormone in Humans The Journal of Clinical Endocrinology and Metabolism. ,vol. 88, pp. 914- 919 ,(2003) , 10.1210/JC.2002-021235
Mary E. Miele, Matthew D. Jewett, Steven F. Goldberg, David L. Hyatt, Christina Morelli, Francesca Gualandi, Paola Rimessi, Deana J. Hicks, Bernard E. Weissman, Giuseppi Barbanti-Brodano, Danny R. Welch, A human melanoma metastasis-suppressor locus maps to 6q16.3-q23. International Journal of Cancer. ,vol. 86, pp. 524- 528 ,(2000) , 10.1002/(SICI)1097-0215(20000515)86:4<524::AID-IJC13>3.0.CO;2-W
Jérôme A.J. Becker, Jean-François Mirjolet, Jérôme Bernard, Emmanuel Burgeon, Marie-Jeanne Simons, Gilbert Vassart, Marc Parmentier, Frédérick Libert, Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors Biochemical and Biophysical Research Communications. ,vol. 326, pp. 677- 686 ,(2005) , 10.1016/J.BBRC.2004.11.094