Metastasis of Hormone Receptor Positive Breast Cancer

摘要: Metastasis, or the movement of tumor cells away from primary to develop independent tumors at a secondary site, is final step in progression toward autonomy host [1–4]. In order metastasize, must invade surrounding tissues and enter bloodstream lymphatics through process termed intravasation. The neovasculature within permeable which allows cell access [5]. Once bloodstream, may remain as single form an embolus with other types. disseminated be capable surviving sheer forces it encounters while traveling vasculature. reaches its target organ adheres either vascular lymphatic endothelium arrests due physical limitation size capillary [6, 7]. will then begin proliferate vessel eventually break leave extravasation. If extravasate, they tissue secondarymass. formation this secondarymass necessary for metastasis. metastasis highly inefficient less than 0.001% 1–4 10 per gram day that establishing masses [8, 9]. While inefficiency number factors including death caused by trauma, immune clearance, anoikis, many 80% complete most steps metastatic cascade, but die site never