Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?

摘要: This review summarizes current knowledge about the mixed lineage kinases (MLKs) and explores their potential role in inflammation immunity. MLKs were identified initially as signalling molecules nervous system. They also shown to play a cell cycle. Further studies documented three groups of MLKs, showed that they may be activated via c-Jun NH2 terminal kinase (JNK) pathway, by Rho GTPases. The biochemistry has been investigated considerable detail. Homodimerization heterodimerization can occur, both autophosphorylation autoinhibition are seen. interaction between JNK interacting protein (JIP) scaffolds, resultant effects on mitogen kinases, have identified. Clearly, there is some redundancy within MLK pathway(s), since mice which lack MLK3 molecule not abnormal. However, using combination biochemical analysis pharmacological inhibitors, several recent vitro suggested only expressed cells immune system (as well system), but implicated selectively pathway follows toll-like receptor ligation innate sentinel cells, such dendritic cell.