Modulation of antibody specificity by tailoring the affinity to cognate antigens
作者： Michael Kinch , William Dall'acqua , Kelly Carles-Knich
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摘要: The present invention relates to methods and compositions designed for the treatment, management, prevention and/o amelioration of various disorders associated with aberrant expression and/or activity one or more Eph receptor tyrosine kinase family members ligands, particularly Ephrins. In particular, provides management , a disorder activity(ies) receptors Ephrins, method comprising administering subject in need thereof an effective amount Eph/Ephrin Modulators. further modulating antibody specificity by tailoring affinity cognate antigens.
glgoo.top参考文章(241)
Joseph Thomas Repine, Daniele Marie Leonard, James Stanley Kaltenbronn, Benzopyranone and quinolone inhibitors of ras farnesyl transferase ,(2000)
Mariano Barbacid, Method for treating cancer using a tyrosine protein kinase inhibitor ,(1992)
Richard N. Tamura, Vito Quaranta, Integrin alpha subunit cytoplasmic domain polypeptides and methods ,(1994)
Bruce A. Lessey, Alphavbeta3integrin as a predictor of endometriosis ,(1994)
Ellen M. Dobrusin, Kevon R. Shuler, Annette M. Doherty, Dennis J. McNamara, Daniele M. Leonard, James S. Kaltenbronn, Judith Sebolt-Leopold, Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase ,(1997)
R. A. Reisfeld, S. Sell, Monoclonal antibodies and cancer therapy UCLA symposium on molecular and cellular biology. Annual meeting. 14. pp. 33- 74 ,(1985)
Vera S. Byers, Robert William Baldwin, Monoclonal Antibodies for Cancer Detection and Therapy ,(1985)
Haian Fu, Protein-protein interactions : methods and applications Published in <b>2004</b> in Totowa NJ by Humana Press. ,(2004)
Victor F. Smolen, LuAnn Ball, Drug product design and performance Wiley. ,(1984)
Medical applications of controlled release CRC Press. ,(1984) , 10.1201/9780429276620