Glycan-specific analytical tools
作者： Robert J. Woods , Loretta Yang
DOI:
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摘要: Provided are lectenz molecules, which mutated carbohydrate processing enzyme enzymes that catalytically inactive and have had their substrate affinity increased by at least 1.2 fold. Further provided methods for making of using such lectenz. Additional proteins following the approach further provided.
lens.org参考文章(87)
Shuanghong Huo, Irina Massova, Peter A. Kollman, Computational alanine scanning of the 1:1 human growth hormone–receptor complex Journal of Computational Chemistry. ,vol. 23, pp. 15- 27 ,(2002) , 10.1002/JCC.1153
Michael J Feldhaus, Robert W Siegel, Yeast display of antibody fragments: a discovery and characterization platform. Journal of Immunological Methods. ,vol. 290, pp. 69- 80 ,(2004) , 10.1016/J.JIM.2004.04.009
Kyung Joo Lee, Shenlan Mao, Chengzao Sun, Changshou Gao, Ola Blixt, Sandra Arrues, Louis G. Hom, Gunnar F. Kaufmann, Timothy Z. Hoffman, Avery R. Coyle, James Paulson, Brunhilde Felding-Habermann, Kim D. Janda, Phage-Display Selection of a Human Single-Chain Fv Antibody Highly Specific for Melanoma and Breast Cancer Cells Using a Chemoenzymatically Synthesized GM3−Carbohydrate Antigen Journal of the American Chemical Society. ,vol. 124, pp. 12439- 12446 ,(2002) , 10.1021/JA020737J
T. P. Treynor, C. L. Vizcarra, D. Nedelcu, S. L. Mayo, Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 48- 53 ,(2007) , 10.1073/PNAS.0609647103
Nora H Barakat, John J Love, Molecular diversity in engineered protein libraries. Current Opinion in Chemical Biology. ,vol. 11, pp. 335- 341 ,(2007) , 10.1016/J.CBPA.2007.05.014
Chad Zimprich, Monika G. Wood, Dieter Klaubert, Mark McDougall, Georgyi V. Los, Keith V. Wood, Aldis Darzins, Lance P. Encell, Covalent tethering of functional groups to proteins and substrates therefor ,(2005)
Irina S. Moreira, Pedro A. Fernandes, Maria J. Ramos, Computational alanine scanning mutagenesis--an improved methodological approach. Journal of Computational Chemistry. ,vol. 28, pp. 644- 654 ,(2007) , 10.1002/JCC.20566
Karl N. Kirschner, Austin B. Yongye, Sarah M. Tschampel, Jorge González-Outeiriño, Charlisa R. Daniels, B. Lachele Foley, Robert J. Woods, GLYCAM06: A generalizable biomolecular force field. Carbohydrates Journal of Computational Chemistry. ,vol. 29, pp. 622- 655 ,(2008) , 10.1002/JCC.20820
Julie Bouckaert, Thomas W. Hamelryck, Lode Wyns, Remy Loris, The Crystal Structures of Man(α1–3)Man(α1-O)Me and Man(α1–6)Man(α1-O)Me in Complex with Concanavalin A Journal of Biological Chemistry. ,vol. 274, pp. 29188- 29195 ,(1999) , 10.1074/JBC.274.41.29188
Michael Kinch, William Dall'acqua, Kelly Carles-Knich, Modulation of antibody specificity by tailoring the affinity to cognate antigens ,(2005)