Cannabis and Cannabinoids: Pharmacology and Rationale for Clinical Use

摘要: There are two types of cannabinoid receptor, CB1 and CB2, both coupled to Gi/o proteins. receptors present on certain central peripheral neurons whereas CB2 have been found mainly in immune cells. Endogenous agonists for also identified. These recent discoveries prompted the development selective receptor ligands. They stimulated renewed interest clinical potential these Two cannabinoids, Δ9-tetrahydrocannabinol nabilone, already prescribed UK or USA as anti-emetics stimulate appetite. Other possible uses include pain relief, suppression muscle spasticity (and pain) associated with multiple sclerosis spinal injury, management glaucoma, bronchial asthma inflammatory disorders, modulation function. Cannabinoid antagonists may applications, example reducing memory deficits ageing neurological diseases. It is important that further preclinical investigations carried out so therapeutic cannabinoids can be exploited full.