A tale of two cannabinoids : The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

摘要: This study examines the current knowledge of physiological and clinical effects tetrahydrocannabinol (THC) cannabidiol (CBD) presents a rationale for their combination in pharmaceutical preparations. Cannabinoid vanilloid receptor as well non-receptor mechanisms are explored, such capability THC CBD to act anti-inflammatory substances independent cyclo-oxygenase (COX) inhibition. is demonstrated antagonise some undesirable including intoxication, sedation tachycardia, while contributing analgesic, anti-emetic, anti-carcinogenic properties its own right. In modern trials, this has permitted administration higher doses THC, providing evidence efficacy safety cannabis based extracts treatment spasticity, central pain lower urinary tract symptoms multiple sclerosis, sleep disturbances, peripheral neuropathic pain, brachial plexus avulsion symptoms, rheumatoid arthritis intractable cancer pain. Prospects future application whole neuroprotection, drug dependency, neoplastic disorders further examined. The hypothesis that increases reducing adverse events supported.