Neuronal electrical high frequency stimulation enhances GABA outflow from human neocortical slices.
作者： M. Mantovani , V. Van Velthoven , H. Fuellgraf , T.J. Feuerstein , A. Moser
DOI: 10.1016/J.NEUINT.2006.02.008
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摘要: Abstract Electrical high frequency stimulation of the globus pallidus internus or subthalamic nucleus has beneficial motor effects in advanced Parkinson's disease. The mechanisms underlying these clinical results remain, however, unclear. From previous studies it is proposed that γ-aminobutyric acid (GABA) system involved effectiveness electrical stimulation. In experiments, human neocortical slices were stimulated electrically (130 Hz) vitro, and GABA outflow was measured after o-phthaldialdehyde sulphite derivatization using HPLC with electrochemical detection. Our could demonstrate (HFS) significantly increased basal presence submaximal concentrations voltage-gated sodium channel opener veratridine. This effect be abolished by antagonists bicuculline picrotoxin. These suggest HFS an activating on GABAergic neuronal terminals slices, depending chloride influx. Since plays a role CNS disorders ganglia, anxiety epilepsy, its modulation may (patho)physiologically relevant.
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