A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair
作者： Alan Ashworth
关键词:
摘要: Cancer cells frequently harbor defects in DNA repair pathways, leading to genomic instability. This can foster tumorigenesis but also provides a weakness the tumor that be exploited therapeutically. Tumors with compromised ability double-strand breaks by homologous recombination, including those BRCA1 and BRCA2, are highly sensitive blockade of single-strand via inhibition enzyme poly(ADP) ribose polymerase. basis for novel synthetic lethal approach cancer therapy.
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