摘要: A total synthesis of aspidophylline A, a pentacyclic akuammiline-type monoterpene indole alkaloid, is described. The features: 1) rapid access to fully functionalized dihydrocarbazole through the desymmetrization readily available 2-allyl-2-(o-nitrophenyl)cyclohexane-1,3-dione; 2) an intramolecular azidoalkoxylation an enecarbamate install both furoindoline ring and azido functionality; 3) an Michael addition for construction 2-azabicyclo[3.3.1]nonane system.
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