Synthetic studies on vincorine: access to the 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole skeleton
作者： Yoshizumi Yasui , Tomoyo Kinugawa , Yoshiji Takemoto
DOI: 10.1039/B907210A
关键词: Sequence (medicine) 、 Stereochemistry 、 Indole test 、 Combinatorial chemistry 、 Skeleton (category theory) 、 Chemistry
摘要: Synthetic studies on vincorine are described; the conversion of 3-aminoethyl-3-alkyloxindoles to 3a,8a-dialkyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indoles has been achieved through an addition–cyclization sequence, and a fully functionalized key intermediate was constructed with this method.
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