Preparation of a new chiral building block containing a benzylic quaternary stereogenic center and a formal total synthesis of (−)-physostigmine
作者： Kaori Asakawa , Naoyoshi Noguchi , Shingo Takashima , Masahisa Nakada
DOI: 10.1016/J.TETASY.2008.09.021
关键词: Absolute configuration 、 Stereocenter 、 Block (telecommunications) 、 Stereochemistry 、 Chemistry 、 Total synthesis 、 Enantioselective synthesis
摘要: Abstract This paper describes the preparation of a new chiral building block containing benzylic quaternary stereogenic center via highly enantioselective PLE-mediated hydrolysis dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well absolute configuration block, which has been elucidated through formal total synthesis (−)-physostigmine.
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