Enantioselective synthesis of (-)-physostigmine.
作者： Seiichi Takano , Emiko Goto , Michiyasu Hirama , Kunio Ogasawara
DOI: 10.1248/CPB.30.2641
关键词:
摘要: The first enantioselective synthesis of (-)-physostigmine (1), a potent cholinesterase-inhibiting alkaloid from Physostigma venenosum Balf., has been accomplished using (S)-(-)-benzyl 2, 3-epoxypropyl ether (5) as chiral synthon.
sci-hub.se 参考文章(1)
Seiichi Takano, Yoko Imamura, Kunio Ogasawara, Enantioselective synthesis of natural mesembrine using (D)-mannitol as a chiral template, a model study for the enantioselective synthesis of the amaryllidaceae alkaloids Tetrahedron Letters. ,vol. 22, pp. 4479- 4482 ,(1981) , 10.1016/S0040-4039(01)93019-9