Polymorphisms of the GSTT1 and GSTM1 genes in polycystic ovary syndrome.
作者： Mariana Mendes Porto Azevedo , Alessandra Bernadete Trovó de Marqui , Bruna Tavares Bacalá , Marly Aparecida Spadotto Balarin , Elisabete Aparecida Mantovanni Rodrigues de Resende
DOI: 10.1590/1806-9282.66.11.1560
关键词:
摘要: BACKGROUND This study aimed to investigate the deletion polymorphisms of genes glutathione S-transferase family GSTT1 and GSTM1 in patients with Polycystic Ovarian Syndrome (PCOS), comparing them a control population. METHODS Blood was collected from 219 women (110 PCOS 109 controls) genomic DNA extracted. For analysis polymorphisms, technique used multiplex PCR. In statistical analysis, chi-square test multiple logistic regression were used. RESULTS There is no association between null genotypes when analyzed separately (P = 0.616 P 0.188). The combined showed differences groups < 0.05), evidencing that genotypic combination positive negative more frequent among patients. multivariate smoking group (OR 0.22; 95% CI - 0.87-0.57; 0.002) while presence history 2, 96; 1.54-5.68; 0.001) PCOS. CONCLUSIONS studied sample, isolated are not associated PCOS, but combination, they may be implicated etiology condition.
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