Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India
作者： ST Raza , S Abbas , A Ahmad , F Ahmed , ZH Zaidi
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摘要: Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has world’s largest number of diabetic subjects. The present study was carried out to investigate association glutathione-S-transferase (GSTM1, GSTT1) fat mass obesity associated (FTO) gene polymorphisms with T2DM patients controls, its role increasing susceptibility T2DM. A total 198 subjects (101 97 controls) participated this study. GSTM1, GSTT1 FTO controls were evaluated by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). We observed significant GSTM1 positive (p = 0.046) null genotypes T2DM, while no found our It seems that can be a predictive marker for early identification population at risk potential GST as needs further studies larger patients.
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