Hypoxia and hypercapnia as respiratory stimulants and depressants.

摘要: Abstract The effect of wide variations in arterial O2 and CO2 tensions on phrenic nerve activity was evaluated anesthetized dogs which were paralyzed so that the physical properties lung chest wall could not influence respiratory neuron response. techniques used allowed effects hypoxia hypercapnia to be assessed either separately or combination. results showed enhanced stimulating response by (1) decreasing tension at phasic begins (2) increasing change produced a given rise tension. However, also augmented depressing peak occurred reducing range over progressive increased activity. suggest usual steady state methods evaluating hypoxic may measuring opposing ventilation; peripheral chemoreceptor; central hypoxia.