Biology of vascular endothelial growth factor and its receptors in head and neck cancer: beyond angiogenesis.
作者： Apostolos Christopoulos , Sun M Ahn , Jonah D Klein , Seungwon Kim
DOI: 10.1002/HED.21588
关键词:
摘要: Angiogenesis is a necessary process for tumor progression and driven through molecular interactions between cancer cells neighboring vascular endothelial cells. The primary mediators of angiogenesis are the growth factors their respective receptors on There several U.S. Food Drug Administration–approved anti-angiogenic agents in clinical use. In head neck there trials assessing efficacy combination with chemoradiation therapy. Although aforementioned have been traditionally viewed as targets, concomitant efforts to understand role these molecules play within this review, we first discuss biology angiogenic proteins targeting treatment. We summarize current therapies squamous cell carcinoma. Finally, additional independent discussed. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
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