Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma.
作者： Benjamin D. Smith , Grace L. Smith , Darryl Carter , Clarence T. Sasaki , Bruce G. Haffty
DOI: 10.1200/JCO.2000.18.10.2046
关键词: Vascular endothelial growth factor 、 Carcinoma 、 Angiogenesis 、 Radiation therapy 、 Medicine 、 Vascular endothelial growth factor A 、 Survival analysis 、 Oncology 、 Internal medicine 、 Metastasis 、 Pathology 、 Epidermoid carcinoma
摘要: PURPOSE: Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in many different tumor types. VEGF levels may affect growth, metastatic potential, and response to radiotherapy. This study assesses the prognostic value of protein a cohort patients with oral oropharyngeal squamous cell carcinomas. The relationships between clinical outcome covariables tumor-node-metastasis stage, disease stage (I IV), grade, margin status, race, sex, age were also determined. PATIENTS AND METHODS: Chart review identified 77 or carcinoma treated gross total surgical resection postoperative radiation 1981 1992. Sufficient follow-up data tissue available 56 (73%). determined using immunohistochemistry. association covariables, was assessed bivariate multivariate model two-sided statistical tests. RESULT...
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