Advancement of antiangiogenic and vascular disrupting agents combined with radiation.

摘要: Technologic advances in therapeutic radiation targeting and delivery have led to improved tumor cure reduced normal tissue toxicity. While further progress these areas is probable, it evident that significant improvements the ratio may result from alterations biologic response of tumors tissues ionizing radiation. By selectively enhancing lethality by unique aspects tumors, local control be achieved without increasing One area ongoing research has focused on identifying potential targets specific manipulated enhance These agents are diverse their origin, action, efficacy. Agents target established or proliferating vasculature a one class such agents. can classified as antiangiogenic agents, primarily inhibit formation new blood vessels, vascular disrupting (VDAs), vasculature. For purpose this chapter, VDAs will discussed separately, however, several compounds been found exhibit both properties.