BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions.
作者： Victoria Del Gaizo Moore , Anthony Letai
DOI: 10.1016/J.CANLET.2011.12.021
关键词:
摘要: Apoptosis is a form of programmed cell death that controlled at the mitochondrion by BCL-2 family proteins. While much has been learned about structure and function these proteins over past two decades, important goal predicting fate decisions in response to toxic stimuli largely unrealized. BH3 profiling functional approach can be used predict cellular responses based on measuring mitochondria perturbation panel domain peptides. proven useful identifying understanding dependence individual anti-apoptotic like or MCL-1. Consequently, it also chemotherapy agents such as ABT-737 target
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