Isolation and characterization of N-hydroxyethyl dithio-desethyl carbodenafil from a health supplement
作者： Chee-Leong Kee , Xiaowei Ge , Cao-Son Tran , Quang-Dong Bui , Nuan-Ping Cheah
DOI: 10.1016/J.JPBA.2020.113431
关键词:
摘要: A new phosphodiesterase type-5 inhibitor (PDE-5i) with thiocarbonyl and thiolactam skeleton has been identified. The unknown compound very similar properties like dithio-desmethyl carbodenafil, which was detected alongside during the screening process. It isolated by a semi-preparative high performance liquid chromatography tandem ultra-violet detector (HPLC-UV). purified characterized using Fourier-transform infrared spectroscopy (FTIR), high-resolution mass spectrometry (HRMS) nuclear magnetic resonance (NMR). is named as N-hydroxyethyl dithio-desethyl carbodenafil due to attachment of hydroxyethyl group heterocyclic nitrogen carbodenafil.
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