Structural characterization of dimethyldithiodenafil and dimethylthiocarbodenafil, analogs of sildenafil
作者： Miho Sakamoto , Jin Suzuki , Yuri Saito , Seiko Shimizu , Kazue Kobayashi
DOI: 10.1016/J.JPBA.2017.09.025
关键词:
摘要: Two analogs of sildenafil (compounds 1 and 2) were detected in three powder products acquired from online drug markets during an LC-UV-MS analysis psychotropic drugs. Their structures established by high-resolution mass spectrometry NMR spectroscopy. Compound was identified as 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione named dimethyldithiodenafil. 2 5-(5-(3,5-dimethylpiperazine-1-carbonothioyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one dimethylthiocarbodenafil. subjected to the phosphodiesterase assay (IC50=0.20nM). The found contain 12-19mg dimethyldithiodenafil 1.4-3.9mg dimethylthiocarbodenafil per tube.
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