DETECTION OF EPIGENETIC MODIFICATIONS

作者: Ost Tobias , Bignell Helen , Steward Michael , Yu Shirong

DOI:

关键词:

摘要: Provided herein are systems and methods for detection of an epigenetic modification in a nucleic acid sequence. The as described may provide substantially unbiased approach detecting modification. method comparison to that amplify sequences having label or moiety associated with

参考文章(13)
Xiuqing Zhang, Yan Wang, Zhongsheng Sun, Xu Han, Mingzhi Ye, High-throughput sequencing method for methylated DNA and use thereof ,(2010)
Christoph Bock, Analysing and interpreting DNA methylation data. Nature Reviews Genetics. ,vol. 13, pp. 705- 719 ,(2012) , 10.1038/NRG3273
J.CIark Susan, Janet Harrison, Cheryl L. Paul, Marianne Frommer, High sensitivity mapping of methylated cytosines. Nucleic Acids Research. ,vol. 22, pp. 2990- 2997 ,(1994) , 10.1093/NAR/22.15.2990
Ruimin Sun, Ye Tian, Xin Chen, TAMeBS: A sensitive bisulfite-sequencing read mapping tool for DNA methylation analysis bioinformatics and biomedicine. pp. 176- 181 ,(2014) , 10.1109/BIBM.2014.6999148
Masahiko Shiraishi, Azumi Sekiguchi, Adam J Oates, Michael J Terry, Yuji Miyamoto, Takao Sekiya, Methyl-CpG binding domain column chromatography as a tool for the analysis of genomic DNA methylation. Analytical Biochemistry. ,vol. 329, pp. 1- 10 ,(2004) , 10.1016/J.AB.2004.02.024
Chun-Xiao Song, Keith E Szulwach, Ye Fu, Qing Dai, Chengqi Yi, Xuekun Li, Yujing Li, Chih-Hsin Chen, Wen Zhang, Xing Jian, Jing Wang, Li Zhang, Timothy J Looney, Baichen Zhang, Lucy A Godley, Leslie M Hicks, Bruce T Lahn, Peng Jin, Chuan He, Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine Nature Biotechnology. ,vol. 29, pp. 68- 72 ,(2011) , 10.1038/NBT.1732
Myunggon Ko, Yun Huang, Anna M. Jankowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaroslaw P. Maciejewski, Anjana Rao, Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Nature. ,vol. 468, pp. 839- 843 ,(2010) , 10.1038/NATURE09586
Sally H. Cross, Jillian A. Charlton, Xinsheng Nan, Adrian P. Bird, Purification of CpG islands using a methylated DNA binding column. Nature Genetics. ,vol. 6, pp. 236- 244 ,(1994) , 10.1038/NG0394-236
Aparna Vasanthakumar, Lucy A. Godley, 5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy. Cancer Genetics and Cytogenetics. ,vol. 208, pp. 167- 177 ,(2015) , 10.1016/J.CANCERGEN.2015.02.009
Ralf Lesche, Juergen Distler, Matthias Schuster, Joern Lewin, Method for Investigating Cytosine Methylations in Dna ,(2006)