The Nucleus Accumbens Shell as a Model of Integrative Subcortical Forebrain Systems Regulating Food Intake

摘要: Publisher Summary Feeding in mammals is a complex behavior, which involves the coordinated integration of multimodal signals from numerous brain regions and periphery. This chapter reviews nucleus accumbens shell (AcbSh) feeding circuit as an example how integrative processes subcortical forebrain contribute to regulation food intake. It only recently that sufficient body data has been accumulated allow us begin understand specific roles played by discrete cell populations, assess importance their relative contributions control normal pathological feeding, investigate these functional populations work together AcbSh circuits containing GABA, glutamate, number neuropeptides play fundamental role controlling The receives variety information afferent fiber systems originating cortical regions. Processed sensory are integrated with regarding energy balance, taste, reward, previously formed associations, results output signal potently regulate neural activity feeding-related involving lateral, arcuate, paraventricular hypothalamic nuclei. Apparently, mediates lateral hypothalamus, both through direct projections altering firing rate neurons interposed medial ventral pallidum. magnitude behavioral specificity AcbSh-mediated suggest pathology might be implicated etiology some eating disorders. Furthermore, amino acid neuropeptide receptors may promising targets for pharmacological therapies designed treat such