Effects of ascorbic acid deficiency on methyl mercury dicyandiamide toxicosis in guinea pigs.

摘要: Methylmercury dicyandiamide (MMD) when given intraperitoneally at a dosage of 4 mg/kg body weight weekly intervals for 3 weeks resulted in death guinea pigs fed an ascorbic acid deficient diet. Controls diet survived during this period as did MMD and adequate In second experiment, containing 22 ppm died within 26 days had severe hemorrhagic ulcerative gastroenteritis coagulative necrosis the liver. Ascorbic controls 34 days. The MMD-containing killed 150 Guinea with 44 20 acute neurologic signs. Pathologic changes were mostly gray matter. 38 whereas 47 Results indicate that deficiency can be factor location severity clinical signs lesions MMD.