Application of the ApcMin/+ mouse model for studying inflammation-associated intestinal tumor

摘要: Abstract Chronic inflammatory diseases of the intestinal tract have been known to increase risk developing a form colorectal cancer as inflammation-associated cancer. The roles inflammation in tumor formation and development ApcMin/+ mice broadly corroborated. mouse model contains point mutation adenomatous polyposis coli (Apc) gene only develops precancerous lesions, benign adenomas. Thus, it provides an excellent vivo system investigate molecular events involved process which may contribute multistep tumorigenesis carcinogenesis. Recent investigations that employ this studied effects alterations, microorganisms, drugs, diet, exercise sleep on development, revealed mechanisms formation, promotion carcinogenesis adenomas with background inflammation. Herein, we focus our review application for studying find anti-inflammation is possible strategy combating tumor, but sometimes cannot help reduce burden. Moreover, various inflammation-related genes are different mechanistic stages intricate regulatory exist whole progression tumor.