The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.
作者： Aline Van Acker , Els Louagie , Jessica Filtjens , Sylvie Taveirne , Els Van Ammel
DOI: 10.1007/S00262-016-1894-6
关键词:
摘要: Ly49E is a member of the Ly49 family NK receptors and distinct from other members this on basis its structural properties, expression pattern ligand recognition. Importantly, receptor high small intestinal colonic intraepithelial lymphocytes (IELs). Intestinal IELs are regulators mucosal immune system contribute to front-line defense at barrier, including anti-tumor response. Whereas most have MHC class-I ligands, we showed that instead triggered by urokinase plasminogen activator (uPA). uPA has been extensively implicated in tumor development, where increased correlates with poor prognosis. As such, investigated role For purpose, compared wild-type mice knockout two established models: ApcMin/+-mediated azoxymethane-induced cancer. Our results indicate does not influence development or progression
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