An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

作者: Clemens Neufert , Christoph Becker , Markus F Neurath

DOI: 10.1038/NPROT.2007.279

关键词: Tumor initiationAzoxymethaneIn vivoInflammationCarcinogenTumor progressionBiologyColorectal cancerCancer researchDiseaseBioinformatics

摘要: … Repeat Steps 3–6 at day 8 of the experiment. … Repeat Steps 3–6 at day 15 of the experiment. … Repeat Steps 3–6 at day 36 of the experiment (by now, each mouse will have had a total of …

参考文章(37)
J. H. Weisburger, Bandaru S. Reddy, Tomio Narisawa, E. L. Wynder, Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and N-methyl-n'-nitro-N-nitrosoguanidine. Cancer Research. ,vol. 34, pp. 2368- 2372 ,(1974)
Isao Okayasu, Shigeru Hatakeyama, Masahiro Yamada, Toshifumi Ohkusa, Yoshio Inagaki, Rintaro Nakaya, A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology. ,vol. 98, pp. 694- 702 ,(1990) , 10.1016/0016-5085(90)90290-H
Bandaru S. Reddy, Siva P. Kumar, Samuel J. Roy, Kenji Tokumo, Effect of Different Levels of Calorie Restriction on Azoxymethane-induced Colon Carcinogenesis in Male F344 Rats Cancer Research. ,vol. 50, pp. 5761- 5766 ,(1990)
A. Moser, H. Pitot, W. Dove, A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse Science. ,vol. 247, pp. 322- 324 ,(1990) , 10.1126/SCIENCE.2296722
Angelo A. Vivona, Baruch Shpitz, Alan Medline, W. Robert Bruce, Kazy Hay, Michael A. Ward, Hartley S. Stern, Steven Gallinger, K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis Carcinogenesis. ,vol. 14, pp. 1777- 1781 ,(1993) , 10.1093/CARCIN/14.9.1777
Hiroyuki Kohno, Rikako Suzuki, Massimo Curini, Francesco Epifano, Federica Maltese, Sylvia Prieto Gonzales, Takuji Tanaka, Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis‐related colon carcinogenesis in mice International Journal of Cancer. ,vol. 118, pp. 2936- 2942 ,(2006) , 10.1002/IJC.21719
Christoph Becker, Massimo C. Fantini, Christoph Schramm, Hans A. Lehr, Stefan Wirtz, Alexei Nikolaev, Jürgen Burg, Susanne Strand, Ralf Kiesslich, Samuel Huber, Hiroaki Ito, Norihiro Nishimoto, Kazuyuki Yoshizaki, Tadamitsu Kishimoto, Peter R. Galle, Manfred Blessing, Stefan Rose-John, Markus F. Neurath, TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling Immunity. ,vol. 21, pp. 491- 501 ,(2004) , 10.1016/J.IMMUNI.2004.07.020
Alexandros Papanikolaou, Ronald C. Shank, Don A. Delker, Andrew Povey, Donald P. Cooper, Daniel W. Rosenberg, Initial Levels of Azoxymethane-Induced DNA Methyl Adducts Are Not Predictive of Tumor Susceptibility in Inbred Mice☆ Toxicology and Applied Pharmacology. ,vol. 150, pp. 196- 203 ,(1998) , 10.1006/TAAP.1998.8393
Steven M. Powell, Gloria M. Petersen, Anne J. Krush, Susan Booker, Jin Jen, Francis M. Giardiello, Stanley R. Hamilton, Bert Vogelstein, Kenneth W. Kinzler, Molecular diagnosis of familial adenomatous polyposis The New England Journal of Medicine. ,vol. 329, pp. 1982- 1987 ,(1994) , 10.1056/NEJM199312303292702
Tetsuji Takayama, Shinichi Katsuki, Yasuo Takahashi, Motoh Ohi, Shuichi Nojiri, Sumio Sakamaki, Junji Kato, Katsuhisa Kogawa, Hirotsugu Miyake, Yoshiro Niitsu, Aberrant Crypt Foci of the Colon as Precursors of Adenoma and Cancer The New England Journal of Medicine. ,vol. 339, pp. 1277- 1284 ,(1998) , 10.1056/NEJM199810293391803