Nanotechnologies for pathogen detection: Future alternatives?

摘要: The development of multiplex and flexible tests allowing the simultaneous analysis pathogens presenting a transfusional risk is real challenge. Current miniaturized platforms have been particularly marked by microarrays. These microsystems allow optical detection hundreds individual targets simultaneously. However, they suffer from low sensitivity their combination with preliminary target amplification step such as PCR necessary. variable level expression infectious genomes interest large diversity complicate amplification. Finally multiple blood-transmitted agents poses numerous difficulties in diagnosis that remain unresolved currently available technologies. Until recently, scientific technological advances for pathogen focused on steps. Today, sample preparation recognized critical area to improve. Nanotechnologies can reach single-cell or molecular scale consequently overcome several current obstacles. They offer new tools improving but also avoiding fluorescent labeling. nano-objects nano-systems technologies offers possibilities potential applications agents.