CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
作者： Chang-Nan Wang , Yu-Jian Liu , Guo-Li Duan , Wei Zhao , Xiao-Han Li
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摘要: Abstract Aims: Mitochondria are known to play a central role in adrenocortical steroidogenesis. Recently, hydrogen sulfide (H2S), gaseous transmitter endogenously produced by cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), has been found improve mitochondrial function. The present study aimed at examining whether CBS CSE expressed adrenal glands, investigated the of these enzymes maintenance function production glucocorticoids cells. Results: Both murine cells account for H2S generation glands. Using combination both vivo vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led oxidative stress dysfunction, which meanwhile resulted blunted corticosterone responses adrenocorticotropic hormone (ACTH). These effects were significantly attenuated treatment donor GYY413...
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