Nucleosome positions predicted through comparative genomics.

作者: Ilya P Ioshikhes , Istvan Albert , Sara J Zanton , B Franklin Pugh

DOI: 10.1038/NG1878

关键词:

摘要: DNA sequence has long been recognized as an important contributor to nucleosome positioning, which the potential regulate access genes. The extent nucleosomal architecture at promoters is delineated by underlying now being worked out. Here we use comparative genomics report a genome-wide map of positioning sequences (NPSs) located in vicinity all Saccharomyces cerevisiae We find that provides very good predictor locations have experimentally mapped small fraction genome. Notably, distinct classes genes possess characteristic arrangements NPSs may be for their regulation. In particular, relatively compact NPS arrangement over promoter region tend TATA box buried and highly regulated chromatin modifying remodeling factors.

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