Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways.

摘要: BACKGROUND Ethnicity, when it is used to mean shared genetic inheritance within a group, has become one of the most important factors in determining prostate carcinoma risk. Genetic polymorphisms were hypothesized be probable explanation for differences risk among ethnic groups. The authors evaluated association between genes involved androgen biosynthesis and metabolism pathway carcinoma. METHODS Two hundred twenty-six patients with pathologic diagnosis sporadic tumor 156 healthy matched (age, group) male controls from large epidemiologic cohort genotyped previously described receptor (AR), 5α-reductase type II (SRD5A2), p450c17 (CYP17), aromatase (CYP19) genes. different also analyzed according age onset, preoperative prostate-specific antigen level, stage, grade. RESULTS The distribution tetranucleotide simple tandem repeat polymorphism (STRP) intron 4 CYP19 was significantly control cancer (P = 0.012). 171 allele 187 associated 0.05 P 0.045, respectively). Conversely, no observed other studied as follow: CAG exon 1 AR, (TA)n dinucleotide 3′ untranslated region, A49T or V89L substitutions SDR5A2, single base pair (bp) (a T C transition) that creates an additional Sp1-type (CCACC box) promoter site CYP17. In patients, repeats TA SDR5A2 are onset < 0.001, respectively). CONCLUSIONS The 171-bp suggests could new indicator prevention men White French ethnogeographic origin. possible individual carries both high- low-risk marker (e.g., CYP17 A2 SRD5A2) resulting overall difference across population. For these reasons, development polygenic model, incorporating multiple loci may maximize chance identifying individuals high-risk genotypes. Cancer 2001;92:1130–7. © 2001 American Society.