Impaired acquisition of conditioned taste aversion memory induced by isoflurane is accompanied with calcineurin activation and Egr-1 down-regulation in amygdala in rats.
作者： Sensen Wang , Lei Zhuang , Xiaoxuan Yang , Qiang Li , Qingsheng Xue
DOI: 10.1016/J.NEULET.2015.09.022
关键词:
摘要: Compared to neutral memory, emotional memory is extremely strong and persistent immediately after acquisition, therefore it may recruit specific mechanisms during acquisition. The calcineurin-dependent engaging early growth response 1 (Egr-1) have been proved determine the strength of establishment. Isoflurane, a widely used inhalation anesthetic, can interfere with acquisition memory. We hypothesized that isoflurane impairs conditioned taste aversion (CTA) in rats Egr-1 expression regulation via calcineurin (CaN) ERK signaling pathway involved isoflurane-induced repression CTA To examine this, we investigated influence on activity CaN, phosphorylation level amygdala training rats. results showed exposure (1.5%, 2h) before impaired Isoflurane increased CaN decreased p-ERK These findings suggest disrupt establishment activation associating down-regulation contribute induced impairment
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