CYP2E1 activity in patients with alcoholic liver disease.
作者： Karin Dilger , Jörg Metzler , Johann Christian Bode , Ulrich Klotz
DOI: 10.1016/S0168-8278(97)80144-4
关键词:
摘要: Abstract Background/Aims: In addition to the possible toxicological impact of cytochrome P4502E1 (CYP2E1) in alcohol-induced liver damage, its activity can be regarded as a variable for dug action patients with alcoholic disease CYP2E1 is involved metabolism several drugs, example, paracetamol and halogenated anesthetics. The purpose our study was acquire detailed knowledge progressingly severe manifestations disease. Methods: concentration ratio 6-hydroxy-chlorzoxazone/chlorzoxazone plasma 2 h after ingestion 500 mg chlorzoxazone (so-called metabolic ratio) has been shown reflect vivo . We examined 56 Caucasian inpatients minor ( n =20), more pronounced =14) =22). Alcohol abusers were compared healthy teetotallers =14). Results: Metabolic ratios increased 3-fold actively drinking (ethanol-induced) abstaining (non-induced) (1.19±0.84 vs. 0.44±0.45, mean±SD, p =0.0008). Conclusions: non-induced patients, decreases line severity CYP2E1-mediated drug significantly impaired
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