Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF- α-Induced Angiogenesis
作者： V. Dixit , A Pandey , H Shao , R. Marks , P. Polverini
关键词:
摘要: B61, a cytokine-inducible endothelial gene product, is the ligand for Eck receptor protein tyrosine kinase (RPTK). Expression of B61-immunoglobulin chimera showed that B61 could act as an angiogenic factor in vivo and chemoattractant cells vitro. The RPTK was activated by tumor necrosis factor-alpha (TNF-alpha) through induction antibody to attenuated angiogenesis induced TNF-alpha but not basic fibroblast growth factor. This finding suggests existence autocrine or paracrine loop involving activation its inducible after inflammatory stimulus, net effect which would be promote angiogenesis, hallmark chronic inflammation.
harvard.edu
sciencemag.org
unirioja.es
elsevier.com参考文章(14)
S D Prionas, L F Fajardo, J Kowalski, A C Allison, H H Kwan, Dual role of tumor necrosis factor-alpha in angiogenesis. American Journal of Pathology. ,vol. 140, pp. 539- 544 ,(1992)
Susan G. Elner, Peter J. Polverini, Steven L. Kunkel, Robert M. Strieter, Csaba L. Martonyi, Victor M. Elner, Alisa E. Koch, Interleukin-8. A corneal factor that induces neovascularization. American Journal of Pathology. ,vol. 141, pp. 1279- 1284 ,(1992)
H Shao, L Lou, A Pandey, E B Pasquale, V M Dixit, cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. Journal of Biological Chemistry. ,vol. 269, pp. 26606- 26609 ,(1994) , 10.1016/S0021-9258(18)47059-7
A W Opipari, H.M. Hu, R Yabkowitz, V.M. Dixit, The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. Journal of Biological Chemistry. ,vol. 267, pp. 12424- 12427 ,(1992) , 10.1016/S0021-9258(18)42292-2
F W Wolf, V M Dixit, R M Marks, V Sarma, T B Shows, Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. Journal of Immunology. ,vol. 148, pp. 3302- 3312 ,(1992)
Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. Journal of Biological Chemistry. ,vol. 269, pp. 30154- 30157 ,(1994) , 10.1016/S0021-9258(18)43790-8
R A Lindberg, T Hunter, cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Molecular and Cellular Biology. ,vol. 10, pp. 6316- 6324 ,(1990) , 10.1128/MCB.10.12.6316
S. Joseph Leibovich, Peter J. Polverini, H. Michael Shepard, David M. Wiseman, Vera Shively, Nureddin Nuseir, Macrophage-induced angiogenesis is mediated by tumour necrosis factor- α Nature. ,vol. 329, pp. 630- 632 ,(1987) , 10.1038/329630A0
Timothy D. Bartley, Robert W. Hunt, Andrew A. Welcher, William J. Boyle, Vann P. Parker, Richard A. Lindberg, Hsieng S. Lu, Anne M. Colombero, Robin L. Elliott, Brenda A. Guthrie, Paige L. Holst, James D. Skrine, Robert J. Toso, Ming Zhang, Elsa Fernandez, Geraldine Trail, Brian Varnum, Yosef Yarden, Tony Hunter, Gary M. Fox, B61 is a ligand for the ECK receptor protein-tyrosine kinase Nature. ,vol. 368, pp. 558- 560 ,(1994) , 10.1038/368558A0
A. Koch, P. Polverini, S. Kunkel, L. Harlow, L. DiPietro, V. Elner, S. Elner, R. Strieter, Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science. ,vol. 258, pp. 1798- 1801 ,(1992) , 10.1126/SCIENCE.1281554