Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication.
作者： Mei-ling Yu , Cui-ling Zhang , Dong-dong Yuan , Xu-hui Tong , Liang Tao
DOI: 10.1248/BPB.B110535
关键词:
摘要: Panax Notoginseng Saponins (PNS) have been well known to anti-tumor activity and enhance cytotoxicity of some cancer chemotherapy agents, but the mechanisms underlying these effects are still unknown. This study investigates effect PNS on cisplatin relationship between this modulation gap junctions (GJ) function by in a transfected cell line. The (0.25-1 µg/mL) was increased presence GJ. Inhibition junction either GJ blocker or interception Connexin (Cx) expression decreased cisplatin. Increasing enhanced cisplatin, only cells with functional (50-200 µg/mL) significantly cytotoxicity, required cells. Exposure for 4 h leads significant dye coupling dose-dependent manner. These results suggest that increases through enhancement activity.
sci-hub.se 参考文章(25)
Jane H-C Lin, Helga Weigel, Maria Luisa Cotrina, Shujun Liu, Earl Bueno, Anker J. Hansen, Thomas W. Hansen, Steven Goldman, Maiken Nedergaard, Gap-junction-mediated propagation and amplification of cell injury. Nature Neuroscience. ,vol. 1, pp. 494- 500 ,(1998) , 10.1038/2210
Chong-Zhi Wang, Xiaoji Luo, Bin Zhang, Wen-Xin Song, Ming Ni, Sangeeta Mehendale, Jing-Tian Xie, Han H Aung, Tong-Chuan He, Chun-Su Yuan, None, Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells Cancer Chemotherapy and Pharmacology. ,vol. 60, pp. 69- 79 ,(2007) , 10.1007/S00280-006-0350-2
Bernhard Erdlenbruch, Marit Nier, Wolfgang Kern, Wolfgang Hiddemann, Arnulf Pekrun, Max Lakomek, Pharmacokinetics of cisplatin and relation to nephrotoxicity in paediatric patients European Journal of Clinical Pharmacology. ,vol. 57, pp. 393- 402 ,(2001) , 10.1007/S002280100319
Motoyoshi Tanaka, H. Barton Grossman, Connexin 26 Gene Therapy of Human Bladder Cancer: Induction of Growth Suppression, Apoptosis, and Synergy with Cisplatin Human Gene Therapy. ,vol. 12, pp. 2225- 2236 ,(2001) , 10.1089/10430340152710568
Takashi Tsujino, Tomoya Nagata, Fumitaka Katoh, Hiroshi Yamasaki, Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication. Cancer Detection and Prevention. ,vol. 31, pp. 332- 338 ,(2007) , 10.1016/J.CDP.2007.06.001
John D. Pitts, Cancer gene therapy: a bystander effect using the gap junctional pathway. Molecular Carcinogenesis. ,vol. 11, pp. 127- 130 ,(1994) , 10.1002/MC.2940110302
Wei Du, Tong-Chuan He, Chun-Su Yuan, Sangeeta Mehendale, Han Aung, Anna Fishbein, Ming Ni, Bin Zhang, Jing-Tian Xie, Chong-Zhi Wang, Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. International Journal of Oncology. ,vol. 31, pp. 1149- 1156 ,(2007) , 10.3892/IJO.31.5.1149
Lubomír Procházka, Jaroslav Turánek, Radek Tesařík, Pavlína Knotigová, Pavlína Polášková, Zdeněk Andrysík, Alois Kozubík, František Žák, Petr Sova, Jiri Neuzil, Miroslav Machala, Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex. Archives of Biochemistry and Biophysics. ,vol. 462, pp. 54- 61 ,(2007) , 10.1016/J.ABB.2007.03.021
James E. Trosko, Chia-Cheng Chang, Mechanism of up-regulated gap junctional intercellular communication during chemoprevention and chemotherapy of cancer Mutation Research. ,vol. 480, pp. 219- 229 ,(2001) , 10.1016/S0027-5107(01)00181-6
Edouard I Azzam, Sonia M de Toledo, John B Little, Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene. ,vol. 22, pp. 7050- 7057 ,(2003) , 10.1038/SJ.ONC.1206961