Protective mechanism of Panax notoginseng saponins on rat hemorrhagic shock model in recovery stage.
作者： Huai-Zheng Liu , Zuo-Liang Liu , Shang-Ping Zhao , Chuan-Zheng Sun , Ming-Shi Yang
DOI: 10.1007/S12013-014-0119-X
关键词:
摘要: To explore protective mechanism of Panax notoginseng saponins (PNS) on rat hemorrhagic shock model in recovery stage. 72 Wistar rats were selected and divided into control group, group PNS with 24 each group. 200 mg/kg was injected intravenously at 60 min stage groups. Changes endotoxin, MPO, IL-6, SOD, MDA TNF α observed 30 120 by ELISA; water content lung intestine detected; HE staining applied to observe morphological change intestinal mucosa, kidney, liver lung; western blot used detect intercellular adhesion molecule-1 (ICAM-1) level tissue tissue. At stage, MDA, IL-6 levels significantly increased compared however SOD decreased, the difference statistically significant (P < 0.05); dose-dependently decreased levels, level, which In results detection, higher than however, after being treated PNS, decreased; showed morphologic cells; Western that tissue, ICAM-1 it lower can increase activity, decrease endotoxin expression Thus, is anti oxidative stress anti-inflammatory pathways, may play an important role mechanism.
springer.com
sci-hub.se 参考文章(30)
Ji-Shan Fan, Dan-Ning Liu, Gang Huang, Zhi-Zhen Xu, Yi Jia, Hai-Gang Zhang, Xiao-Hui Li, Feng-Tian He, Panax notoginseng saponins attenuate atherosclerosis via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression Journal of Ethnopharmacology. ,vol. 142, pp. 732- 738 ,(2012) , 10.1016/J.JEP.2012.05.053
Philip C. Spinella, John B. Holcomb, Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Reviews. ,vol. 23, pp. 231- 240 ,(2009) , 10.1016/J.BLRE.2009.07.003
Christian Münch, John O’Brien, Anne Bertolotti, Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 3548- 3553 ,(2011) , 10.1073/PNAS.1017275108
Mei-ling Yu, Cui-ling Zhang, Dong-dong Yuan, Xu-hui Tong, Liang Tao, Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication. Biological & Pharmaceutical Bulletin. ,vol. 35, pp. 1230- 1237 ,(2012) , 10.1248/BPB.B110535
Eek Joong Park, Jun Hee Lee, Guann-Yi Yu, Guobin He, Syed Raza Ali, Ryan G. Holzer, Christoph H. Österreicher, Hiroyuki Takahashi, Michael Karin, Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression Cell. ,vol. 140, pp. 197- 208 ,(2010) , 10.1016/J.CELL.2009.12.052
Ernest E Moore, Frederick A Moore, Timothy C Fabian, Andrew C Bernard, Gerard J Fulda, David B Hoyt, Therese M Duane, Leonard J Weireter Jr, Gerardo A Gomez, Mark D Cipolle, George H Rodman Jr, Mark A Malangoni, George A Hides, Laurel A Omert, Steven A Gould, PolyHeme Study Group, None, Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial. Journal of The American College of Surgeons. ,vol. 208, pp. 1- 13 ,(2009) , 10.1016/J.JAMCOLLSURG.2008.09.023
Timea Csak, Michal Ganz, Justin Pespisa, Karen Kodys, Angela Dolganiuc, Gyongyi Szabo, Fatty Acid and Endotoxin Activate Inflammasomes in Mouse Hepatocytes that Release Danger Signals to Stimulate Immune Cells Hepatology. ,vol. 54, pp. 133- 144 ,(2011) , 10.1002/HEP.24341
Houfu Liu, Junling Yang, Feifei Du, Xiumei Gao, Xutao Ma, Yuhong Huang, Fang Xu, Wei Niu, Fengqing Wang, Yu Mao, Yan Sun, Tong Lu, Changxiao Liu, Boli Zhang, Chuan Li, None, Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats Drug Metabolism and Disposition. ,vol. 37, pp. 2290- 2298 ,(2009) , 10.1124/DMD.109.029819
Yin-Chu Si, Jian-Ping Zhang, Chun-E Xie, Li-Juan Zhang, Xiang-Ning Jiang, Effects of Panax Notoginseng Saponins on Proliferation and Differentiation of Rat Hippocampal Neural Stem Cells The American Journal of Chinese Medicine. ,vol. 39, pp. 999- 1013 ,(2011) , 10.1142/S0192415X11009366
Stephen J Nicholls, WH Wilson Tang, Danielle Brennan, Marie-Luise Brennan, Shirley Mann, Steven E Nissen, Stanley L Hazen, Risk Prediction with Serial Myeloperoxidase Monitoring in Patients with Acute Chest Pain Clinical Chemistry. ,vol. 57, pp. 1762- 1770 ,(2011) , 10.1373/CLINCHEM.2011.166827