New Players in Immunity to Tuberculosis: The Host Microbiome, Lung Epithelium, and Innate Immune Cells.

摘要: Tuberculosis (TB) is a highly contagious infection and devastating chronic disease, causing 10.4 million new infections 1.8 deaths every year globally. Efforts to control eradicate TB are hampered by the rapid emergence of drug resistance limited efficacy only available vaccine, BCG. Immunological events in airways lungs major importance determining whether exposure Mycobacterium tuberculosis (Mtb) results successful or protective immunity. Several studies have demonstrated that host microbiota constant contact with immune system, thus continually directs nature responses occurring during infections. However, little known about its role eventual outcome mycobacterial infection. In this review, we highlight changes microbial composition respiratory tract gut been linked alteration responses, risk, prevention, treatment TB. addition, summarize our current understanding alveolar epithelial cells innate their interaction Mtb early Extensive warranted fully understand all-inclusive lung microbiota, epithelium resulting adaptive pathogenesis and/or protection from Novel interventions aimed at influencing system immunity will shape future strategies prevention for