The Concept of Fitness and Drug Resistance in Leishmania

摘要: Central to the concept of host-parasite interaction is idea that adaptation stress living conditions imposed by pressure a drug not cost-free. Costs arise if represents conflict with traits may compromise intrinsically parasite properties essential for its survival like, example, virulence. Such trade-offs between fitness components will certainly control life-history evolution and maintenance genetic diversity. Leishmaniasis disease affects people mostly in tropical subtropical areas. Failure successfully cure leishmaniasis often due resistance. Until now, whether resistance Leishmania compromises proficiency, terms infectivity or metabolism, has been systematically evaluated. The costs represented this development parasite, referred as “costs virulence,” are capacity establish an infection other characters (e.g., within-host growth, production transmission stages). These considered major ingredients coevolutionary process because they can prevent spread fixation all-resistant host all-infectious genotypes thereby preserve diversity both populations. Therefore, here we examine cost under chemotherapeutic failure analyze physiological changes expressed drug-resistant reflect modification vitality compared drug-sensitive parasites. Finally, clinical implications also discussed.