Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma
作者： Soumya C. Iyer , Ashidha Gopal , Devaraj Halagowder
DOI: 10.1007/S11010-015-2471-6
关键词:
摘要: Hepatocellular carcinoma is one of the most common malignancies worldwide and evidence suggests that Ras signaling regulates various hallmarks cancer via regulating several effector pathways such as ERK PI3K. The aim present study to understand efficacy a flavonoid myricetin for first time in inhibiting downstream target p21 activated kinase 1 (PAK1) pathway hepatocellular carcinoma. analysis gene expression revealed inhibits PAK1 by abrogating Ras-mediated decelerating Wnt signaling, Erk/Akt, thereby inducing intrinsic caspase-mediated mitochondrial apoptosis downregulating anti-apoptotic Bcl-2 survivin upregulating pro-apoptotic Bax. results also provide striking development HCC coordinate abrogation MAPK/ERK PI3K/AKT their Wnt/β-catenin pathway, thus being promising candidate prevention therapy.
springer.com
sci-hub.se 参考文章(41)
Eric C H Lai, Wan-Yee Lau, Hepatocellular carcinoma: current management and recent advances. Hepatobiliary & Pancreatic Diseases International. ,vol. 7, pp. 237- 257 ,(2008)
Hans Ulrich Bergmeyer, Erich Bernt, Colorimetric Assay of Reitman and Frankel Methods of Enzymatic Analysis (Second Edition)#R##N#Volume 2. pp. 735- 739 ,(1974) , 10.1016/B978-0-12-091302-2.50044-X
Kathryn Balmanno, Simon D. Chell, Annette S. Gillings, Shaista Hayat, Simon J. Cook, Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines† International Journal of Cancer. ,vol. 125, pp. 2332- 2341 ,(2009) , 10.1002/IJC.24604
Kian C. Ong, Hoon-Eng Khoo, Biological effects of myricetin General Pharmacology: The Vascular System. ,vol. 29, pp. 121- 126 ,(1997) , 10.1016/S0306-3623(96)00421-1
F. Xavier Bosch, Josepa Ribes, Ramon Cléries, Mireia Díaz, Epidemiology of Hepatocellular Carcinoma Clinics in Liver Disease. ,vol. 9, pp. 191- 211 ,(2005) , 10.1016/J.CLD.2004.12.009
Mahaboob S. Khan, Devaraj Halagowder, S Niranjali Devaraj, Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats. Food and Chemical Toxicology. ,vol. 49, pp. 173- 178 ,(2011) , 10.1016/J.FCT.2010.10.013
Nhi Huynh, Kevin H. Liu, Graham S. Baldwin, Hong He, P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways Biochimica et Biophysica Acta. ,vol. 1803, pp. 1106- 1113 ,(2010) , 10.1016/J.BBAMCR.2010.05.007
Yuan-Wei Shih, Pei-Fen Wu, Yi -Chieh Lee, Ming-Der Shi, Tai-An Chiang, Myricetin suppresses invasion and migration of human lung adenocarcinoma A549 cells: possible mediation by blocking the ERK signaling pathway. Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 3490- 3499 ,(2009) , 10.1021/JF900124R
Rozita Bagheri-Yarmand, Ratna K. Vadlamudi, Rui-An Wang, John Mendelsohn, Rakesh Kumar, Vascular Endothelial Growth Factor Up-regulation via p21-activated Kinase-1 Signaling Regulates Heregulin-β1-mediated Angiogenesis Journal of Biological Chemistry. ,vol. 275, pp. 39451- 39457 ,(2000) , 10.1074/JBC.M006150200
Maria Almeida, Li Han, Teresita Bellido, Stavros C. Manolagas, Stavroula Kousteni, Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT Journal of Biological Chemistry. ,vol. 280, pp. 41342- 41351 ,(2005) , 10.1074/JBC.M502168200