Genomics and Evolution of the TRIM Gene Family
作者： Germana Meroni
DOI: 10.1007/978-1-4614-5398-7_1
关键词:
摘要: The TRIM family comprises proteins characterized by the presence of tripartite motif that is composed a RING domain, one or two B-box domains and Coiled-coil region. These are implicated in plethora cellular processes such as apoptosis, cell cycle regulation, muscular physiology innate immune response. Consistently, their alteration results several pathological conditions emphasizing theirmedical relevance. TRIMmembers domain structure underscores common biochemical function E3 ligases within ubiquitylation cascade, which then translated into diverse biological processes. represent largest families mammals counting human almost 70 members. metazoan-specific have been now identified species although great increase number was generated vertebrate species. important expansion TRIMgenes underlie success module process. Furthermore, massive diversification among achieved through fast evolution genes pathogen
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