Sphingosine and ceramide signalling in apoptosis
作者： Joanna Woodcock
DOI: 10.1080/15216540600871118
关键词:
摘要: The sphingomyelin pathway is activated in response to many apoptotic stimuli leading the accumulation of breakdown products ceramide and sphingosine. Ceramide has received much attention as an second messenger whereas sphingosine largely been overlooked a mediator apoptosis. Recent studies however provide strong clues role for identification effectors reveal possible mechanism involved sphingosine-mediated cell death. This mini-review overviews current knowledge apoptosis discusses their biological effects. review attempts reconcile effects these lipids with downstream that have identified.
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