Ceramide and N,N,N-Trimethylphytosphingosine-Iodide (TMP-I)-Based Lipid Nanoparticles for Cancer Therapy

作者: Prabagar Balakrishnan , Chung Kil Song , Alexander Jahn , Hyun-Jong Cho

DOI: 10.1007/S11095-015-1780-5

关键词:

摘要: Purpose To evaluate the anti-tumor effect of ceramide or trimethylphytosphingosine-iodide (TMP-I) containing solid lipid nanoparticles (SLNs) prepared using trymyristin, phosphatidylcholine (PC), and Pluronic P85 (P85) for intravenous delivery docetaxel.

参考文章(29)
Sen-itiroh Hakomori, Yasuyuki Igarashi, Qinghong Zhou, Mohammad Nisar, Katsuyuki Endo, Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice. Cancer Research. ,vol. 51, pp. 1613- 1618 ,(1991)
Rainer H Müller, Karsten Mäder, Sven Gohla, Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 50, pp. 161- 177 ,(2000) , 10.1016/S0939-6411(00)00087-4
Moon Taek Park, Tae Hwan Kim, Su Jae Lee, Hee Yong Chung, Jung A. Kang, Sangwoo Bae, Seongman Kang, Weon Ik Choi, Jung A. Choi, Chul Koo Cho, Yun Sil Lee, Sujong Kim, Chang Mo Kang, Phytosphingosine Induces Apoptotic Cell Death via Caspase 8 Activation and Bax Translocation in Human Cancer Cells Clinical Cancer Research. ,vol. 9, pp. 878- 885 ,(2003)
Chao-Feng Mu, Prabagar Balakrishnan, Fu-De Cui, Yong-Mei Yin, Yong-Bok Lee, Han-Gon Choi, Chul Soon Yong, Suk-Jae Chung, Chang-Koo Shim, Dae-Duk Kim, None, The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel. Biomaterials. ,vol. 31, pp. 2371- 2379 ,(2010) , 10.1016/J.BIOMATERIALS.2009.11.102
Annette zur Mühlen, Cora Schwarz, Wolfgang Mehnert, Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 45, pp. 149- 155 ,(1998) , 10.1016/S0939-6411(97)00150-1
Joanna Woodcock, Sphingosine and ceramide signalling in apoptosis Iubmb Life. ,vol. 58, pp. 462- 466 ,(2006) , 10.1080/15216540600871118
Wolfgang Mehnert, Karsten Mäder, Solid lipid nanoparticles Advanced Drug Delivery Reviews. ,vol. 64, pp. 83- 101 ,(2012) , 10.1016/J.ADDR.2012.09.021
Martin Werle, Natural and Synthetic Polymers as Inhibitors of Drug Efflux Pumps Pharmaceutical Research. ,vol. 25, pp. 500- 511 ,(2008) , 10.1007/S11095-007-9347-8
Elke Persohn, Annalisa Canta, S. Schoepfer, Martin Traebert, Lutz Mueller, Alessandra Gilardini, Stefania Galbiati, Gabriella Nicolini, Arianna Scuteri, Francesca Lanzani, Giuditta Giussani, Guido Cavaletti, Morphological and morphometric analysis of paclitaxel and docetaxel-induced peripheral neuropathy in rats. European Journal of Cancer. ,vol. 41, pp. 1460- 1466 ,(2005) , 10.1016/J.EJCA.2005.04.006
Maria Laura Immordino, Paola Brusa, Silvia Arpicco, Barbara Stella, Franco Dosio, Luigi Cattel, Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel Journal of Controlled Release. ,vol. 91, pp. 417- 429 ,(2003) , 10.1016/S0168-3659(03)00271-2