Genetics and Genito-Urinary Cancer
作者： Mark R. Morris , Eamonn R. Maher
DOI: 10.1007/978-0-85729-482-1_3
关键词:
摘要: Cancer results from the accumulation of genetic (and epigenetic) alterations that causes dysregulation multiple intracellular and intercellular networks. In normal cells these networks ensure cellular proliferation tissue structure is tightly regulated. There are key tumour suppressor genes (TSG) such as p53 pRB protoncogenic RAS/RAF/MAPK cascade commonly dysregulated in many cancer types including genito-urinary cancers. This chapter describes how pathways contributes to specific cell attributes required for malignant progression. Moreover, their related disrupted cancers (such loss pVHL function clear Renal Cell Carcinoma (RCC) Androgen Receptor amplification prostate cancer) discussed detail. Our current understanding genetics molecular biology hereditary also described. While there germ-line gene mutations result inherited kidney (VHL, FLCN, SDHB) (BRCA2, HOXB13) high penetrance have yet be identified bladder testicular cancer.
springer.com
sci-hub.st 参考文章(98)
Domenico Ribatti, Endogenous inhibitors of angiogenesis: a historical review. Leukemia Research. ,vol. 33, pp. 638- 644 ,(2009) , 10.1016/J.LEUKRES.2008.11.019
Sabine Zöchbauer-Müller, Arthur Sagalowsky, John D. Minna, Bogdan Czerniak, Funda Vakar-Lopez, Adi F. Gazdar, Shinichi Toyooka, Arvind K. Virmani, Alfredo J. Farinas, Kiyomi O. Toyooka, Kenichi Harada, Riichiroh Maruyama, Aberrant Promoter Methylation Profile of Bladder Cancer and Its Relationship to Clinicopathological Features Cancer Research. ,vol. 61, pp. 8659- 8663 ,(2001)
Jerry W. Shay, Woodring E. Wright, Hayflick, his limit, and cellular ageing Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 72- 76 ,(2000) , 10.1038/35036093
Michael M. Lieber, David G. Bostwick, Junqi Qian, Robert B. Jenkins, Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. Cancer Research. ,vol. 57, pp. 524- 531 ,(1997)
Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459
Catherine Morrissey, Alonso Martinez, Malgorzata Zatyka, Angelo Agathanggelou, Sofia Honorio, Dewi Astuti, Neil V Morgan, Holger Moch, Frances M Richards, Takeshi Kishida, Masahiro Yao, Peter Schraml, Farida Latif, Eamonn R Maher, None, Epigenetic Inactivation of the RASSF1A 3p21.3 Tumor Suppressor Gene in Both Clear Cell and Papillary Renal Cell Carcinoma Cancer Research. ,vol. 61, pp. 7277- 7281 ,(2001)
C. Turnbull, N. Rahman, Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour. International Journal of Andrology. ,vol. 34, ,(2011) , 10.1111/J.1365-2605.2011.01162.X
L. R�nnstrand, Signal transduction via the stem cell factor receptor/c-Kit. Cellular and Molecular Life Sciences. ,vol. 61, pp. 2535- 2548 ,(2004) , 10.1007/S00018-004-4189-6
Alan Horwich, Janet Shipley, Robert Huddart, Testicular germ-cell cancer The Lancet. ,vol. 367, pp. 754- 765 ,(2006) , 10.1016/S0140-6736(06)68305-0
, Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nature Genetics. ,vol. 30, pp. 406- 410 ,(2002) , 10.1038/NG849