Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour.
作者： C. Turnbull , N. Rahman
DOI: 10.1111/J.1365-2605.2011.01162.X
关键词: Carcinogenesis 、 Genetic epidemiology 、 Disease 、 Genetics 、 Biology 、 Genetic predisposition 、 Genome-wide association study 、 Cancer 、 Single-nucleotide polymorphism 、 Genetic association
摘要: Testicular germ-cell tumour (TGCT) is the most common cancer in young men, and genetic epidemiological studies suggest that disease has a strong basis. Until 2009, very little of this component had been explained. Genome-wide association have since identified eight SNPs at six loci which together account for approximately 15% risk TGCT offer novel biological insights into testicular oncogenesis. In review, we summarize epidemiology TGCT, detail contribution genome-wide made to our understanding basis reflect on how future technological advances may assist revealing remaining factors underlying susceptibility.
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