IQGAP1 and its binding proteins control diverse biological functions
作者： Colin D. White , Huseyin H. Erdemir , David B. Sacks
DOI: 10.1016/J.CELLSIG.2011.12.005
关键词:
摘要: IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to humans. The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates multiple essential aspects mammalian biology. IQGAP1 mediates these effects by binding and regulating function numerous interacting proteins. Over ninety reported associate with either directly or as part larger complex. In this review, we summarise those partners that last five years. molecular mechanisms interactions contribute functions receptors their signalling cascades, small GTPase function, cytoskeletal dynamics, neuronal regulation intracellular trafficking are evaluated. evidence has accumulated recently validates role expands repertoire cellular activities it participates.
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