Oligomerization and nanocluster organization render specificity

摘要: Nanoclusters are anchored to membranes, either within them or in the cytoplasm latched onto cytoskeleton, whose reorganization can regulate their activity. have been viewed terms of cooperativity and activation; here we perceive nanocluster organization from a conformational standpoint. This leads us suggest that while single molecules encode activity, nanoclusters induce specificity, this is main evolutionary aim. Distinct, isoform-specific drive preferred effector (and ligand) interactions thereby designate signalling pathways. The absence detailed structural information across nanocluster, due size dynamics, hinders an in-depth grasp its mechanistic features; however, available data already capture some principles functional ‘raison d'etre’. Collectively, clustering lends stability reduces likelihood proteolytic cleavage; it also increases effective local concentration enables efficient cooperative activation. However, does not determine ability molecule function. Drugs targeting attenuate activity by hampering cooperativity; may perturb activation signalling, which originate themselves, as such, likely endure. What then major role nanoclustering? Assuming evolved first, with subsequent increase cellular complexity emergence highly similar isoform variants, evolution faced threat promiscuity. We reason potential risk was thwarted oligomerization clustering; confers higher concomitant extra layer control. In our Ras example, will be more accurate dimer than monomer, where isomer specificity could compromised.