IQGAP1: A Regulator of Intracellular Spacetime Relativity

摘要: Activating and inhibiting receptors of lymphocytes collect valuable information about their mikros kosmos. This is essential to initiate or turn off complex signaling pathways. Irrespective these advances, our knowledge on how intracellular activation cascades are coordinated in a spatiotemporal manner far from complete. Among multiple explanations, the scaffolding proteins have emerged as critical piece this evolutionary tangram. many, IQGAP1 one that coordinate possesses protein interaction motifs achieve its functions. Using domains, has been shown regulate number cellular events. includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling, Pak/Raf/Mek1/2-mediated Erk1/2 activation, formation maestrosome, E-cadherin, CD44-mediated glycogen synthase kinase-3/adenomatous polyposis coli-mediated β-catenin activation. In review, we summarize recent developments exciting new findings functions IQGAP1.